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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '11501a971604d6bc796f4add02f18f569237246b1f3ec8eab689d3097cb1cd5f' 
  AND token = 'QuiFrBr6Wv3plQIdWweZ8TP9su5eJPRdYEIOA0CBUp0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}