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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '927d54bc321dda61d74af34501cbf9d2d8b3aac44c65c914aa52704165346c35' 
  AND token = 'c2/wT1c9LtIlPRgaTC1NmSJF1OG/H2XRdd0tvYiUlOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}