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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '646aa9965303537e6d48667f6cd967b2fac989ac6907be8261ae93c778aa0d10' 
  AND token = 'TOUofysZR3MfOFQhFpk8kL/3mxOwVrJCJd/A38CgTyE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}