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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = 'b784bf74544f57e8f0d89a257053e761fcebfb28d1a02167a9fde0b8887f25fc' 
  AND token = 'ZXTMEDQ+aP5QkBYbOs4rrsClDe8r8ZCafquUySoEYp8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}