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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '22e8f2a383bacb079f309f8abc44b57ec4133de321b0748cdbc945d1c01f049d' 
  AND token = 'bOpinm28c56uf5m03VMIU3d8F5CKLVXCdDUtT1YO4G8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}