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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '974157376b606c833b7612cce977cfc34709c62fd6c9ff565e9e4eb3be5dc110' 
  AND token = 'kwm+TRFH5G22fOInWUca0Wk6xRE5ogZ2TrKgCbs9VxA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}