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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '4b6c1e379e914e7022ebceb5b10b9679cf88ee3e718064b3e749acf41f26c8a3' 
  AND token = 'v8Uth+nkprg8p1RF3cUyUfmdrYOC0Q/yEXjoFtQq9Mk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}