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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '74a2ec170438fa3c099605db8bc1b1ba388f18abdd1da77a123195e2326a2f57' 
  AND token = '0U1Nbel8daHzdTIOXFtxAFHoXAcmH/M8VzbkHh0M7Ko=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}