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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '495595978fe6a9a08e0da586720d52a906eebcef971e3a4b74f04dd4dca1df5b' 
  AND token = 'NW+0SM/IOGWdZWynbyjQRSNyA8JGIQWbiybrumUWnlc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}