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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '422f67217dff732f703145e844ff3eec5cefc80be7d39e26e905ccc00bbbc93e' 
  AND token = '2G1HhaafizKOG39qWpAPJMMjYoAR3xRFygFje46yxmc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}