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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '5af7ec6fb6691e9ac79379c742034faf078a01a44b2aa93f8ffab435895eaa3f' 
  AND token = 'B/+xL/AzviOLRM0ECak74m3Dxbf1BDj7OBDNkO0oBUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}