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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '51726fcdfb46c43e6194e0fc4833c76b68186b8b70219178337bbaed985a3d8a' 
  AND token = 'y0TuXlBtS9vAezuxvxE0pFnV6BE4HU6UEfurKVoCpp4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}