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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '2143a15cc8609183e6960f632ac28bd7a782d58879382c5e7b5e235c69000721' 
  AND token = 'k8tTrzv3pNfBu1AS29Du1dqyaP4Bcv3JG9P7RItZBLE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}