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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '78b5a35a2d8fff536c74e3167c63670292503bf6f3ce28e6d8f4f023a2286829' 
  AND token = 'oaVp1KxtowD/xsQ4zfj/5/E6KrgumpxHXIc/4QLQLWE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}