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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '010b2a56037f4402bea61483667c215fb2c89929f899c554ead19a9a03f38a0a' 
  AND token = 'PIIY7I3yDK9ELj2p8YOmmfxCQW+i6sPuuDB31Lybno0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}