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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '2b2c2fefcacdaea97fde844167aae38a0e8ad778fccf3264990046a0b5af4a61' 
  AND token = '1Y1A7AJ22nhlfq9LDN30pbIUPe9MqRAoIM5rg0B65rI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}