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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '0b21447c54e7666a61275c170ed138484a3ef0bd7723bfa85254defb5e0546ed' 
  AND token = 'zKaKsLC0FNP2DK39GK/u+py4tmxXtnCFCu7UmakYfRE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}