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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '497c5b856a83febd9022c7f1c5ae8e1486062f4260222a01d5697335afe7591c' 
  AND token = 'dBj0OiameaRqxBkv7opDL78otrnEl/UvpioPwAo5DGw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}