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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '86acb147b695e388cf9fa11af1666fe515ff647e63b6fe2f797df6048013d49a' 
  AND token = 'cxyMdinKShTmevsM3Lb3VyrJGINFWvgxVz9TaTMO7ZQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}