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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '4fa5e379acf98e0e1feef23c5aac63d0d0a0a69a1180555750ee4c087f110405' 
  AND token = 'MFrbFrBsZfBLBx8iv5Fs069NWdzUgsi1UeTwAZEixlI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}