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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '14340f3ffb492189a4f589bc4218e1f36b2d3721f409beaeb47130e3eede5985' 
  AND token = 'EWGwMhD2p5fRYWfZ2YmMYFxFp7nXp68AphaK0bCUNYc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}