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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = 'c22cf2a60be58132b14afecc627e80e80f6db82df0b13cd39321569dbc563085' 
  AND token = 'btK0ivwW2DZskkAH9DcoHcvj01LkLDqxaiZYTCbqOMQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}