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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '186af2e7b873afc02675ade581dd6ef643899d600da6a8cdb964d9bcf470e190' 
  AND token = 'ItEogtueYNnpkTLEaa6GrEm7uKsTbIb3qJ7pMtC15Vs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}