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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '6d53e171374e4ef36ff039492fab021ef33ba08a11434efda0edd5c8d47a1d2a' 
  AND token = 'F0nIIM0C22dAGaCmqyefT+MKDMHe2Mg8jXdRqLmd7T8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}