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SELECT 
  1 
FROM 
  cscart_june_setupec_print_temp_designs 
WHERE 
  session_id = '540R-TZ9M-4JBV-JVCH-B663-DRX2-0OBZ-18WZ' 
  AND product_id = 125 
  AND expires_at > 1781897127 
  AND confirmed = 'Y' 
LIMIT 
  1

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}