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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = 'af41c97a2d74a53b711b582a5618e3c9cc5a424b437fcf546dccee18f9229a4f' 
  AND token = 'dKFJaR85N5o+0Ojz6BC1qAXs7oYjSgOn0QXsOL7b3t4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}