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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '721c49e041a5fa1cfb83c80d203fe0740a36958040c82afda7a6a55c2c567bec' 
  AND token = 'Uf/eS9HPtA3tQF7WS1fbjSnh08dbdlQuSG2LSfN/hj4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}