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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '4afeb7b1ccd275130729ea534e3796b525663a1d0e2c2987b6ddd6a4e4a2c5a3' 
  AND token = 'HN3N1k6MDwJyX1pSO32nAK6ahY39vJo6ZCnA67k5Qwg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}