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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '25a02356279a27c7d0a12760aa079833440860be3bf2649177887da2e91caef6' 
  AND token = 'UpqRugEOa5DpZ13zVO6z+RsIO4qIOnFa+d5teHL0Qho=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}