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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '431f83a1aedd04994888427bf1a7dd88b93aed4718287999c18b60b76c60ba7d' 
  AND token = 'JiOVeHy6S0BjH14UmHiWdAWcLTcKir8RwjRRt0hk6Qg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}