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SELECT 
  1 
FROM 
  cscart_june_setupec_print_temp_designs 
WHERE 
  session_id = 'X9FB-7RNO-4KWU-90GU-OS1U-9WFX-0ZED-12M3' 
  AND product_id = 221 
  AND expires_at > 1781878748 
  AND confirmed = 'Y' 
LIMIT 
  1

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}