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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '4a5ac18abb94a7a81e82e7ff9ed75485b1616737ebae158853c05194bb85ac43' 
  AND token = 'sdHF7U4Ev+IL0Wpx99UvPCBmDgcAoiG+DcE4wo3sxNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}