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SELECT 
  1 
FROM 
  cscart_june_setupec_print_temp_designs 
WHERE 
  session_id = 'RT13-XPQG-COMN-HALR-UUG4-L16Q-QXYD-RP1V' 
  AND product_id = 221 
  AND expires_at > 1781817978 
  AND confirmed = 'Y' 
LIMIT 
  1

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}