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SELECT 
  1 
FROM 
  cscart_june_setuplock_keys 
WHERE 
  key_id = '78bb24f886049ff0cfcc4be056a81f46ab1c6614d0affe4f797297dde413a181' 
  AND token = 'qTe2vLCwoxRUwc/BBUkNk3h7JRT4T0rbEZdwB15VCO8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}