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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'ba99423d58f006629d784b3b1b27bccfad67f8bb3ec21afc405c3618cec7b4c2' 
  AND token = 'bnRSSKbu2G3m9BUJMGtXtyk+RLZQbeulyZH+Hxwh13M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}