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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'd0e27225ebbe69a61480301cdba9d58fdb0b229d04da4a03c03066bc3daef6b8' 
  AND token = '/Rnxy8FZcGgWJyqKEjkhuod3FxZiSJPDuOXgGv6CdpE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}