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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'f7c018374d8c45dc5a54fd4dd9c82d939d4558f03f626164bcdfc610124c0acf' 
  AND token = 'IWlB/qCQjF3MUpQGv1cn5xy2UaAWWWZWDtfIBYKNfEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}