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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'c45d1249cfd45fe68bfad02ce149f25864b2033a533ee665a2412c7f70940fa5' 
  AND token = 'yiyzrwFMxOAS/6AHxbS+jk2fERXBgNMQsMIl/lsAUG8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}