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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '0e121e5c7bb8f9b73eed8ac363c2dddd091d1307a8092b26121f1dd589fb798a' 
  AND token = 'U8H7m2vPLnA4p8sHdkf+zk6vnrKRD1y9nG60UvFiTZM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}