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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '253c80d0581bbc2b2c1701c29b2c4864ad4291dca47dead632aa4faf4adb2b59' 
  AND token = '7GfCZ1EnryjDBMXpaJ4vpVpZUbW52vmN2etJo3WJdN4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}