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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '78259ff70dacd53678748c16ddf521df486ff1fcd064fca7a7aa979f97e7d1a5' 
  AND token = 'uenVS8gU4j6/GpE2yOd8OOGsJFdIRQuQkZT4+sM6Nmw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}