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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '39492d6306bdf2e050b13ec3399be3f8b82efc63990fd52ae86d185c8b79c3a2' 
  AND token = 'QO2aYhkvChYEQ+M9k6aYxzb9wIPXPFcBVvEO3nRoV44=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}