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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '456cda64599cc83b33c99bf2673549abada0a4449a07d452d21d97ed03a75df4' 
  AND token = 'AJuQVTYTTt62s/in1duxeI5CB0kpK6OMR/EoaBBBZgw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}