Sandbox

SELECT 
  1 
FROM 
  cscart_aprilec_print_temp_designs 
WHERE 
  session_id = 'E458-4VVA-N6G2-4GC4-SQYY-5MHZ-SQ9O-BV2H' 
  AND product_id = 100 
  AND expires_at > 1778154625 
  AND confirmed = 'Y' 
LIMIT 
  1

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}