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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '3b80fd66e116c9f0840b95e57b0af5c0dc1744145744042ec27000f60031d2b2' 
  AND token = 'CIrzhpAWXJrjYyTDOq8rRpab838UVLxN0AI2tiZ+DNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}