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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '621bea313789712f5408577d6cc8d2925c82baf0cb93e2fbc010f0b5a517a00c' 
  AND token = 'uI4APP3l5fnrawZc1kF+GHGqEX5U6HJDAAdCy+eKSPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}