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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '8a681e1c63fe0a0264f58f224353aa2d91375b47e217e41b11893da51295bdcb' 
  AND token = 'ELF2YTGEHnSKy/OqrSnxKRi91s5/tgdG9CXoCfQ1jL8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}