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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'b2ad0bf018fe7532c7ed5a6b922dce8eb0ea9cd21850f771af323d3137226011' 
  AND token = 'EDbzfkFbCg9sZGZxzqB4c7q/zG2DBtbPUWl453SPRK0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}