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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '22d78025665a016d440c931a338557c5e1c20eea89a9ec6748a709b35a706f16' 
  AND token = 'TuSFGW+2okU4eXTNP3h1gDRb3b4i0qUN7gNQY5DfQcM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}