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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '8a4049e28dd1748235fe5e34580ff18507fc9da0282a627295b90a170dcb6623' 
  AND token = 's/HiPowxrz1UnLddOKSW73vPEKPXlrC+laHKpi9LliE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}